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Article

Colorectal cancer organoid models uncover oxaliplatin-resistant mechanisms at single cell resolution

22 Sept 2022

Abstract excerpt

PURPOSE: Oxaliplatin-based chemotherapy is a standard treatment for advanced colorectal cancer (CRC) patients. However, chemoresistance-induced resistance is an essential cause for mortality. Therefore, it is necessary to study the mechanism of drug resistance in CRC. METHODS: Here, we established two strains of patient-derived organoids (PDOs) selected from oxaliplatin-resistant and treatment-naïve CRC patients....

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PMID: 36136268
DOI: 10.1007/s13402-022-00705-5

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