Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancer

31 May 2024

Abstract excerpt

BACKGROUND: Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence of chemoresistance poses a significant clinical challenge. The persistence of ovarian cancer stem cells (OCSCs) at the end of primary treatment contributes to disease recurrence. Here, we hypothesized that the extracellular matrix protects CSCs during chemotherapy and supports their tumorigenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cell Adhesion Molecules Research
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38822429
DOI: 10.1186/s13046-024-03083-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerPMID 38822429Read ↗

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancerSemantic proximity Read ↗

A comprehensive overview of ovarian cancer stem cells: correlation with high recurrence rate, underlying mechanisms, and therapeutic opportunitiesSemantic proximity Read ↗

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapySemantic proximity Read ↗

Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signalingSemantic proximity Read ↗

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapySemantic proximity Read ↗

Frizzled-7 Identifies Platinum Tolerant Ovarian Cancer Cells Susceptible to FerroptosisSemantic proximity Read ↗

The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian CancerSemantic proximity Read ↗

Ovarian cancer stem cell-specific gene expression profiling and targeted drug prescreeningSemantic proximity Read ↗

Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance.Semantic proximity Read ↗

Tumor microenvironment-induced FOXM1 regulates ovarian cancer stemnessSemantic proximity Read ↗

Matrix Gla Protein drives stemness and tumor initiation in ovarian cancerSemantic proximity Read ↗

Matrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.