Article

Integrin-linked kinase-frizzled 7 interaction maintains cancer stem cells to drive platinum resistance in ovarian cancer

2024-03-13

Abstract excerpt

<title>Abstract</title> <p>Background Platinum-based chemotherapy regimens are a mainstay in the management of ovarian cancer (OC), but emergence of chemoresistance poses a significant clinical challenge. The persistence of ovarian cancer stem cells (OCSCs) at the end of primary treatment contributes to disease recurrence. Here, we hypothesized that the extracellular matrix protects CSCs during chemotherapy and...

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Literature Corpus work: a5c3c35b-a492-5fb5-9c11-694ce76ba9f9
DOI: 10.21203/rs.3.rs-4086737/v1

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