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Article

Impact of selection bias on polygenic risk score estimates in healthcare settings.

Psychological medicine - 1 Nov 2023

Lee Younga Heather, Thaweethai Tanayott, Sheu Yi-Han, Feng Yen-Chen Anne, Karlson Elizabeth W, Ge Tian, Kraft Peter, Smoller Jordan W

Abstract excerpt

BACKGROUND: Hospital-based biobanks are being increasingly considered as a resource for translating polygenic risk scores (PRS) into clinical practice. However, since these biobanks originate from patient populations, there is a possibility of bias in polygenic risk estimation due to overrepresentation of patients with higher frequency of healthcare interactions. METHODS: PRS for schizophrenia, bipolar disorder,...

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Identifiers

PMID: 37226828
DOI: 10.1017/S0033291723001186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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