Article

Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits

2020-09-07

Abstract excerpt

Due to the complexity of linkage disequilibrium (LD) and gene regulation, understanding the genetic basis of common complex traits remains a major challenge. We develop a Bayesian model (BayesRR-RC) implemented in a hybrid-parallel algorithm that scales to whole-genome sequence data on many hundreds of thousands of individuals, taking 22 seconds per iteration to estimate the inclusion probabilities and effect size...

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Literature Corpus work: da10001d-253d-5aee-9328-eaa7e4f1cc4b
DOI: 10.1101/2020.09.04.20188433

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