Article

Deep generative models generate mRNA sequences with enhanced translation capacity and stability

2024-06-20

Abstract excerpt

Despite the tremendous success of messenger RNA (mRNA) COVID-19 vaccines, the extension of this modality to a broader spectrum of diseases necessitates substantial enhancements, particularly in the design of mRNAs with elevated expression levels and extended durability. Here we present GEMORNA, a deep generative model designed to generate novel mRNA coding sequences (CDSs) and untranslated regions (UTRs) with supe...

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Literature Corpus work: c47a495f-2532-594f-9e9c-114f1b253a2c
DOI: 10.1101/2024.06.20.599727

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