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Article

SARITA: a large language model for generating the S1 subunit of the SARS-CoV-2 spike protein.

Briefings in bioinformatics - 2 Jul 2025

Rancati Simone, Nicora Giovanna, Bergomi Laura, Buonocore Tommaso Mario, Czyz Daniel M, Parimbelli Enea, Bellazzi Riccardo, Salemi Marco, Prosperi Mattia, Marini Simone

Abstract excerpt

BACKGROUND: The COVID-19 pandemic has caused over 776 million infections and 7 million deaths globally between December 2019 and November 2024. Since the emergence of the original Wuhan strain, SARS-CoV-2 has evolved into multiple variants-including Alpha, Delta, and Omicron-primarily through mutations in the Spike glycoprotein. The S1 subunit, which binds the human angiotensin-converting enzyme 2 (ACE2)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40755284
DOI: 10.1093/bib/bbaf384
PMCID: PMC12319310

Genes

ACE2
GPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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