Article

Capturing Natural Evolution in Function-guided RNA Design via Genomic Foundation Models

2025-04-09

Abstract excerpt

<h4>Summary</h4> RNAs play critical roles in gene expression regulation, catalysis, genetic information transmission, and immune response. However, current RNA engineering approaches face limitations in designing RNA for efficient in vivo folding and functional execution. Here, we present a novel, zero-shot strategy that integrates genomic large language models (LLMs) with inverse folding models (IFMs) to generat...

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Literature Corpus work: 762de5e3-8df2-5b47-86a3-4c1a872a8acb
DOI: 10.1101/2025.04.08.647793

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