Article

Unlocking Programmable and Creative RNA Sequence Design with RDiffusion

2026-06-13

Abstract excerpt

RNA, a pillar of the central dogma, has shaped three billion years of evolution. Despite cataloging tens of millions of non-coding RNAs and annotating millions, we have barely scratched the surface of the vast, unexplored RNA sequence space. Here, we introduce RDiffusion, a discrete-diffusion-based generative transformer model for RNA sequence design. Conditioned on diverse biological features, such as desired fun...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab092b1c-c2a5-548b-949d-d9bd9ed398bc
DOI: 10.64898/2026.06.13.732023

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Unlocking Programmable and Creative RNA Sequence Design with RDiffusionDOI 10.64898/2026.06.13.732023Read

Generative inverse design of RNA structure and function with gRNAdeSemantic proximity Read

Capturing Natural Evolution in Function-guided RNA Design via Genomic Foundation ModelsSemantic proximity Read

A generative-AI framework for target-Specific MicroRNAs towards RNAi-based drug designSemantic proximity Read

Helix: a structure-aware deep learning model for accurate prediction of A-to-I RNA editing by endogenous ADARsSemantic proximity Read

Generative and predictive neural networks for the design of functional RNA moleculesSemantic proximity Read

Generative machine learning of ADAR substrates for precise and efficient RNA editingSemantic proximity Read

Generative AI for Drug Discovery and Protein Design: The Next Frontier in AI-Driven Molecular ScienceSemantic proximity Read

Generative modeling for RNA splicing prediction and designSemantic proximity Read

yakRNA Design: A semantic multimodal RNA composerSemantic proximity Read

Towards parsimonious generative modeling of RNA families.Semantic proximity Read

Deep generative models generate mRNA sequences with enhanced translation capacity and stabilitySemantic proximity Read

DrugHIVE: Target-specific spatial drug design and optimization with a hierarchical generative modelSemantic proximity Read