Article

UTRGAN: Learning to Generate 5’ UTR Sequences for Optimized Translation Efficiency and Gene Expression

2023-02-01

Abstract excerpt

The 5’ untranslated region (5’ UTR) of mRNA is crucial for the molecule’s translatability and stability, making it essential for designing synthetic biological circuits for high and stable protein expression. Several UTR sequences are patented and widely used in laboratories. This paper presents UTRGAN, a Generative Adversarial Network (GAN)-based model for generating 5’ UTR sequences, coupled with an optimization...

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Literature Corpus work: a835d339-311c-5a85-82e2-9c40208984b7
DOI: 10.1101/2023.01.30.526198

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