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Article

A critical role of retinoic acid concentration for the induction of a fully human-like atrial action potential phenotype in hiPSC-CM.

Stem cell reports - 14 Nov 2023

Schulz Carl, Sönmez Muhammed, Krause Julia, Schwedhelm Edzard, Bangfen Pan, Alihodzic Dzenefa, Hansen Arne, Eschenhagen Thomas, Christ Torsten

Abstract excerpt

Retinoic acid (RA) induces an atrial phenotype in human induced pluripotent stem cells (hiPSCs), but expression of atrium-selective currents such as the ultrarapid (IKur) and acetylcholine-stimulated K+ current is variable and less than in the adult human atrium. We suspected methodological issues and systematically investigated the concentration dependency of RA. RA treatment increased IKur concentration...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37922915
DOI: 10.1016/j.stemcr.2023.10.006
PMCID: PMC10679650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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