Article

A critical role of retinoic acid concentration for the induction of a fully human-like atrial phenotype in hiPSC-CM

2023-01-03

Abstract excerpt

<h4>Summary</h4> Retinoic acid (RA) induces an atrial phenotype in human induced pluripotent stem cells (hiPSC), but expression of atrium-selective currents such as the ultrarapid (I Kur ) and acetylcholine-stimulated K + current (I K,ACh ) is variable and less than in adult human atrium. We suspected methodological issues and systematically investigated the concentration-dependency of RA. RA treatment increas...

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Literature Corpus work: 6eefef25-f823-54c7-884c-d19eda6365ee
DOI: 10.1101/2023.01.03.522611

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