Article

A Defined and Cost-Efficient Strategy for Generating Functionally Quiescent Human iPSC-Derived Cardiac Fibroblasts

2026-03-13

Abstract excerpt

<title>Abstract</title> <p> Cardiac fibroblasts (CFs) are central regulators of myocardial structure, extracellular matrix homeostasis, and pathological remodeling, yet robust <italic>ex vivo</italic> experimental access to naïve human CFs remains limited. Primary human CFs exhibit restricted proliferative capacity, donor-to-donor variability, and rapid phenotypic drift in culture, constraining their utility f...

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Literature Corpus work: 62a0501e-0323-530d-8125-a476cd61333e
DOI: 10.21203/rs.3.rs-9098586/v1

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