Article

Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse model

2022-02-06

Abstract excerpt

Kleefstra syndrome in humans is characterized by general delay in development, intellectual disability and autistic features. The mouse model of this disease ( Ehmt1 +/- ) expresses anxiety, autistic-like traits, and aberrant social interactions with non-cagemates. To investigate how Ehmt1 +/- mice behave with unfamiliar conspecifics, we allowed adult, male animals to freely interact for 10 minutes in a neutral...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c455f1c6-e471-5772-98cc-ec907f4df421
DOI: 10.1101/2022.02.03.478985

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defensive and offensive behaviors in social interaction settings in a Kleefstra syndrome mouse modelDOI 10.1101/2022.02.03.478985Read

Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice.Semantic proximity Read

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes.Semantic proximity Read

Mouse behavioral assays relevant to the symptoms of autism.Semantic proximity Read

Day-to-day spontaneous social behaviours is quantitatively and qualitatively affected in a 16p11.2 deletion mouse modelSemantic proximity Read

Abnormal social behaviors and dysfunction of autism-related genes associated with daily agonistic interactions in miceSemantic proximity Read

Behavioral Phenotyping of an Improved Mouse Model of Phelan-McDermid Syndrome with a Complete Deletion of the Shank3 Gene.Semantic proximity Read

Sociability and motor functions in Shank1 mutant mice.Semantic proximity Read

Autism-like behavioral phenotypes in BTBR T+tf/J mice.Semantic proximity Read

A 16p11.2 deletion mouse model displays quantitatively and qualitatively different behaviours in sociability and social novelty over short- and long-term observationSemantic proximity Read

Magel2 knockout mice manifest altered social phenotypes and a deficit in preference for social novelty.Semantic proximity Read

Abnormalities of social interactions and home-cage behavior in a mouse model of Rett syndrome.Semantic proximity Read

Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation.Semantic proximity Read