Article
Mouse behavioral assays relevant to the symptoms of autism.
Brain pathology (Zurich, Switzerland) - 1 Oct 2007
Crawley Jacqueline N
Abstract excerpt
While the cause of autism remains unknown, the high concordance between monozygotic twins supports a strong genetic component. The importance of genetic factors in autism encourages the development of mutant mouse models, to advance our understanding of biological mechanisms underlying autistic behaviors. Mouse models of human neuropsychiatric diseases are designed to optimize (i) face validity (resemblance to...
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