Article
Reduced exploration, increased anxiety, and altered social behavior: Autistic-like features of euchromatin histone methyltransferase 1 heterozygous knockout mice.
Behavioural brain research - 17 Mar 2010
Balemans Monique C M, Huibers Manon M H, Eikelenboom Nathalie W D, Kuipers Arthur J, van Summeren Rik C J, Pijpers Michael M C A, Tachibana Makoto, Shinkai Yoichi, van Bokhoven Hans, Van der Zee Catharina E E M
Abstract excerpt
The 9q34.3 subtelomeric deletion syndrome is a newly defined mental retardation syndrome, caused by haplo-insufficiency of the euchromatin histone methyltransferase 1 (EHMT1) gene. Patients also have childhood hypotonia, facial dysmorphisms, delay in reaching developmental milestones, and behavioral problems like aggressive outbursts, hypoactivity, or autistic-like features. Male and female heterozygous Ehmt1...
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