Article
Autism-like behavioral phenotypes in BTBR T+tf/J mice.
Genes, brain, and behavior - 1 Mar 2008
McFarlane H G, Kusek G K, Yang M, Phoenix J L, Bolivar V J, Crawley J N
Abstract excerpt
Autism is a behaviorally defined neurodevelopmental disorder of unknown etiology. Mouse models with face validity to the core symptoms offer an experimental approach to test hypotheses about the causes of autism and translational tools to evaluate potential treatments. We discovered that the inbred mouse strain BTBR T+tf/J (BTBR) incorporates multiple behavioral phenotypes relevant to all three diagnostic...
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