Article

Scaling up IL glutamatergic outputs to the amygdala alleviates opioid induced hyperalgesia in male rats

2023-05-16

Abstract excerpt

Opioids are the frontline analgesics for managing various types of pain. Paradoxically, repeated use of opioid analgesics may cause an exacerbated pain state known as opioid-induced hyperalgesia (OIH), which hinders effective clinical intervention for sever pain. Although the cellular and molecular mechanisms for OIH have been tested at different level on the pain pathway, little is known about the neural circuits...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c42a7bf0-3f6c-5588-b3d1-a621dbb7344b
DOI: 10.21203/rs.3.rs-2901486/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Scaling up IL glutamatergic outputs to the amygdala alleviates opioid induced hyperalgesia in male ratsDOI 10.21203/rs.3.rs-2901486/v1Read

Glutamatergic neurons in the infralimbic cortex for motivational response of pain relief induced by electroacupunctureSemantic proximity Read

The medial orbitofrontal cortex mediates neuropathic pain and anxiodepressive-like behaviors via two distinct pathwaysSemantic proximity Read

Central amygdalar PKCδ neurons mediate fentanyl withdrawalSemantic proximity Read

Opioid receptor expressing neurons of the central amygdala gate behavioral effects of ketamine in miceSemantic proximity Read

The role of amygdala calcitonin gene-related peptide receptors on the development of persistent bladder pain in miceSemantic proximity Read

Parabrachial CGRP Neurons Regulate Opioid ReinforcementSemantic proximity Read

Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulationSemantic proximity Read

mGluR5 in ECCCK to BLA Circuit Modulates Depressive-Like Phenotypes through CCK Signaling.Semantic proximity Read

GluA1 phosphorylation contributes to postsynaptic amplification of neuropathic pain in the insular cortex.Semantic proximity Read

Olfactory Stimulation Successfully Modulates the Neurochemical, Biochemical and Behavioral Phenotypes of the Visceral Pain.Semantic proximity Read

Mimicking opioid analgesia in cortical pain circuitsSemantic proximity Read

Predicting Pain Using a Data-Driven Agent-Based Model of the Bilateral Central AmygdalaSemantic proximity Read