Article

Opioid- and NMDA-receptor-dependent neural plasticity mediates long-term analgesia from motor cortical stimulation

2026-07-07

Abstract excerpt

Exogenous opioids that activate mu-opioid receptors (MORs) in nociceptive circuits mediate transient pain relief lasting minutes to hours but have more limited utility for treating chronic pain. By comparison, electrical or magnetic stimulation of the motor cortex can induce pain relief lasting weeks, for which the underlying mechanisms have remained unclear. Here we report an unconventional role for endogenous op...

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Literature Corpus work: f5303bfc-3b3d-58fe-b60c-161beec37b76
DOI: 10.64898/2026.07.01.735554

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