Article

Sirt1 Protects Against Hippocampal Atrophy and its Induced Cognitive Impairment in Middle-aged Mice

2021-12-28

Abstract excerpt

<h4>Background: </h4> Sirtuin 1 ( Sirt1 ) is a recognized longevity gene and has been shown to be associated with aging and its related diseases. Hippocampal volume is considered to be the most sensitive brain imaging phenotype for cognition, but the effect of Sirt1 on hippocampal morphology during aging has not been reported. <h4>Results: </h4>: Herein, we investigated the effect of conditional Sirt1 knockdown on...

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Literature Corpus work: c41a205a-cc66-5467-99ea-45b4f4f13f69
DOI: 10.21203/rs.3.rs-1126398/v1

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