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Article

Sirtuins in cognitive ageing and Alzheimer's disease

10 Feb 2012

Abstract excerpt

PURPOSE OF REVIEW: Sirtuins are a family of enzymes highly conserved in evolution and involved in mechanisms known to promote healthy ageing and longevity. This review aims to discuss recent advances in understanding the role of sirtuins, in particular mammalian SIRT1, in promoting longevity and its potential molecular basis for neuroprotection against cognitive ageing and Alzheimer's disease pathology. RECENT...

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PMID: 22327552
DOI: 10.1097/yco.0b013e32835112c1

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