Article
PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.
Nature communications - 20 Dec 2019
Cai Weijia, Su Liya, Liao Lili, Liu Zongzhi Z, Langbein Lauren, Dulaimi Essel, Testa Joseph R, Uzzo Robert G, Zhong Zhijiu, Jiang Wei, Yan Qin, Zhang Qing, Yang Haifeng
Abstract excerpt
p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney cancer, encodes PBRM1. Here, we identify PBRM1 as a reader for p53 acetylation on lysine 382 (K382Ac) through its bromodomain 4 (BD4). Notably, mutations on key...
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