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Article

Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer.

Genome medicine - 12 May 2016

Narayan Soumil, Bader Gary D, Reimand Jüri

Abstract excerpt

BACKGROUND: Discovery of cancer drivers is a major goal of cancer research. Driver genes and pathways are often predicted using mutation frequency, assuming that statistically significant recurrence of specific somatic mutations across independent samples indicates their importance in cancer. However, many mutations, including known cancer drivers, are not observed at high frequency. Fortunately, abundant...

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Topics

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Share to Acetylation
Share to Databases, Genetic
Share to Gene Regulatory Networks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation Rate

Share to Protein Interaction Maps

Share to Protein Processing, Post-Translational

Share to Survival Analysis

Share to Ubiquitination

Source

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Identifiers

PMID: 27175787
DOI: 10.1186/s13073-016-0311-2
PMCID: PMC4864925

Genes

AKT1
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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