Article

Elucidating BAP1-microRNA regulatory networks in mesothelioma

2018-01-01

Abstract excerpt

BRCA-1 Associated Protein 1 (BAP1) is a nuclear deubiquitylase (DUB) frequently inactivated by mutation in specific cancers including malignant pleural mesothelioma (MPM). Mutations cause loss of nuclear BAP1 expression or catalytic inactivation and, as BAP1 regulates both ubiquitylation and transcription, its loss in cancer may dysregulate expression of specific proteins, and potentially non-coding RNAs such as m...

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Literature Corpus work: 62d71372-4a82-575e-807d-3e14887fcd76
DOI: 10.17638/03021120

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