Article
Distinguishing between driver and passenger mutations in individual cancer genomes by network enrichment analysis.
BMC bioinformatics - 19 Sept 2014
Merid Simon Kebede, Goranskaya Daria, Alexeyenko Andrey
Abstract excerpt
BACKGROUND: In somatic cancer genomes, delineating genuine driver mutations against a background of multiple passenger events is a challenging task. The difficulty of determining function from sequence data and the low frequency of mutations are increasingly hindering the search for novel, less common cancer drivers. The accumulation of extensive amounts of data on somatic point and copy number alterations...
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