Article

Influence of Cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in Zanzibar

2021-01-26

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>The antimalarial drug amodiaquine, a commonly used long acting partner drug in artemisinin-based combination therapy, is metabolized to active desethyl-amodiaquine (DEAQ) by cytochrome P450 2C8 (CYP2C8). The <italic>CYP2C8 </italic>gene carries several polymorphisms including the more frequent minor alleles<italic> CYP2C8*2</italic> and <italic>CYP2C8*3</italic>....

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Literature Corpus work: c3d29a81-bf87-5898-a5e7-d3e4f8b7ac0c
DOI: 10.21203/rs.3.rs-104894/v2

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