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Article

Cytochrome P450 single nucleotide polymorphisms in an indigenous Tanzanian population: a concern about the metabolism of artemisinin-based combinations.

Malaria journal - 3 Nov 2014

Marwa Karol J, Schmidt Theresa, Sjögren Maria, Minzi Omary M S, Kamugisha Erasmus, Swedberg Göte

Abstract excerpt

BACKGROUND: Artemisinin-based combinations currently recommended for treatment of uncomplicated Plasmodium falciparum malaria in many countries of sub-Saharan Africa are substrates of CYP enzymes. The cytochrome enzyme system is responsible for metabolism of about 80-90% of clinically used drugs. It is, therefore, important to obtain the pharmacogenetics of the population in the region with respect to these...

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Identifiers

PMID: 25363545
DOI: 10.1186/1475-2875-13-420
PMCID: PMC4228099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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