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Article

Prevalence in Northern Angola of Cytochrome P450 (CYP) 2C8 Alleles Associated with Amodiaquine Decreased Metabolism.

The American journal of tropical medicine and hygiene - 4 Feb 2026

Kiaco Kinanga, Nóbrega de Sousa Tais, Rosário Virgílio do, Gil José Pedro, Lopes Dinora

Abstract excerpt

Amodiaquine-artesunate is one of the recommended options by the Angolan National Malaria Control Program for the treatment of uncomplicated malaria and for malaria seasonal chemoprevention. CYP2C8 is a critical enzyme in the metabolism of amodiaquine. The CYP2C8 gene harbors alleles coding for less active enzymes that have been linked to amodiaquine-associated adverse events. In this work, we analyzed the...

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Amodiaquine
Angola
Antimalarials
Child, Preschool
Cytochrome P-450 CYP2C8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Malaria, Falciparum

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Identifiers

PMID: 41662739
DOI: 10.4269/ajtmh.24-0710
PMCID: PMC12874844

Genes

CYP2C8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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