Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amodiaquine pharmacogenetics.

Pharmacogenomics - 1 Oct 2008

Gil Jose Pedro

Abstract excerpt

Amodiaquine is a central drug in the new global strategy of combination therapies for the control of malaria. Amodiaquine is mainly metabolized hepatically towards its major active metabolite desethylamodiaquine, by the polymorphic P450 isoform CYP2C8. Amodiaquine is associated with rare but serious side effects, as well as with relatively frequent mild ones. These are expected to be at least partially related to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Half-Life
Share to Malaria, Falciparum
Share to Plasmodium falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amodiaquine

Share to Antimalarials

Share to Cytochrome P-450 Enzyme System

Share to Endemic Diseases

Share to Forecasting

Source

Identifiers

PMID: 18855526
DOI: 10.2217/14622416.9.10.1385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amodiaquine pharmacogenetics.PMID 18855526Read ↗

CYP2C8 and Antimalaria Drug EfficacySemantic proximity Read ↗

The pharmacogenetics of antimalaria artemisinin combination therapy.Semantic proximity Read ↗

PharmacogeneticsSemantic proximity Read ↗

Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.Semantic proximity Read ↗

Prevalence in Northern Angola of Cytochrome P450 (CYP) 2C8 Alleles Associated with Amodiaquine Decreased Metabolism.Semantic proximity Read ↗

An update on pharmacogenetic factors influencing the metabolism and toxicity of artemisinin-based combination therapy in the treatment of malariaSemantic proximity Read ↗

Influence of Cytochrome P450 (CYP) 2C8 polymorphisms on the efficacy and tolerability of artesunate-amodiaquine treatment of uncomplicated Plasmodium falciparum malaria in ZanzibarSemantic proximity Read ↗

A Review of Pharmacogenetics of Antimalarials and Associated Clinical Implications.Semantic proximity Read ↗

Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles.Semantic proximity Read ↗

Polymorphisms in Cytochrome P450 genes: implications for Plasmodium vivax malaria treatment in Brazil.Semantic proximity Read ↗

[Pharmacogenetics and antiepileptic drug metabolism: implication of genetic variants in cytochromes P450].Semantic proximity Read ↗

The Effect of SNPs in CYP450 in Chloroquine/PrimaquinePlasmodium VivaxMalaria TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.