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Article

CYP2C8 and Antimalaria Drug Efficacy

1 Feb 2007

Abstract excerpt

Malaria is a major infectious disease. In the last 10 years it has killed more than 20 million people, mainly small children in Africa. The highly efficacious artemisinine combination therapy is being launched globally, constituting the main hope for fighting the disease. Amodiaquine is a main partner in these combinations. Amodiaquine is almost entirely metabolized by the polymorphic cytochrome P450 (CYP)...

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PMID: 17286541
DOI: 10.2217/14622416.8.2.187

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