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JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast Cancer

2026-02-05

Abstract excerpt

The JAK-STAT pathway (JSP) is a well-known oncogenic cascade; however, recent clinical trials have detected JSP upregulation in breast cancer following anti-PD1 immunotherapy. This paradoxical observation warrants further investigation into JSP’s intercellular heterogeneity, tumor dynamics, molecular mechanisms, and clinical implications for immunotherapy. JSP expression showed dynamic shifts during breast cancer...

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Literature Corpus work
7a0cfffd-e2fc-581a-a273-86c5665115d7
DOI
10.64898/2026.02.03.703506
Open publication

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JAK-STAT Pathway Heterogeneity Governs Immunotherapy Response in Breast CancerDOI 10.64898/2026.02.03.703506
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