Article

Host association induces genome changes in <i>Candida albicans</i> which alters its virulence

2020-04-23

Abstract excerpt

Candida albicans is an opportunistic fungal pathogen of humans that is typically diploid yet, has a highly labile genome that is tolerant of large-scale perturbations including chromosomal aneuploidy and loss-of-heterozygosity events. The ability to rapidly generate genetic variation is crucial for C. albicans to adapt to changing or stress environments, like those encountered in the host. Genetic variation occur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 101d660d-fcb4-5229-ab69-bf4eda76d66d
DOI: 10.1101/2020.04.22.056002

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Host association induces genome changes in <i>Candida albicans</i> which alters its virulenceDOI 10.1101/2020.04.22.056002Read

Host-Induced Genome Instability Rapidly Generates Phenotypic Variation across Candida albicans Strains and Ploidy States.Semantic proximity Read

Genome plasticity in Candida albicans: A cutting-edge strategy for evolution, adaptation, and survivalSemantic proximity Read

Host Defense Mechanisms Induce Genome Instability Leading to Rapid Evolution in an Opportunistic Fungal PathogenSemantic proximity Read

The Impact of Gene Dosage and Heterozygosity on the Diploid Pathobiont Candida albicansSemantic proximity Read

Genomic plasticity of the human fungal pathogen Candida albicans.Semantic proximity Read

The Genome of the Human Pathogen <i>Candida albicans</i> is Shaped by Mutation and Cryptic Sexual RecombinationSemantic proximity Read

Stress Alters Rates and Types of Loss of Heterozygosity in Candida albicansSemantic proximity Read

Genomic variation in C. albicans.Semantic proximity Read

Virulence phenotypes result from an interaction between pathogen ploidy and genetic backgroundSemantic proximity Read

A Global Analysis of Mutations Accompanying Microevolution in the Heterozygous Diploid Pathogen <i>Candida albicans</i>Semantic proximity Read

The fitness costs and benefits of trisomy of each <i>Candida albicans</i> chromosomeSemantic proximity Read

Analysis of Repair Mechanisms following an Induced Double-Strand Break Uncovers Recessive Deleterious Alleles in the Candida albicans Diploid Genome.Semantic proximity Read