Article

Muscle spatial lipidomics identifies early ALS-associated lipid remodeling in presymptomatic SOD1G93A mice

2026-07-16

Abstract excerpt

<title>Abstract</title> <p> Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motoneuron (MN) degeneration, leading to progressive muscle weakness and paralysis. In the absence of a cure, the diagnosis of ALS remains challenging, often requiring up to one year for confirmation. The skeletal muscle is now recognized as an early pathogenic driver rat...

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Literature Corpus work: c3b247d5-a678-51c7-9d46-273222c19a76
DOI: 10.21203/rs.3.rs-10307267/v1

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