Article

Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis

2024-07-17

Abstract excerpt

<h4>ABSTRACT</h4> Amyotrophic Lateral Sclerosis (ALS) is a multisystemic neurodegenerative disorder, with accumulating evidence indicating metabolic disruptions in the skeletal muscle preceding disease symptoms, rather than them manifesting as a secondary consequence of motor neuron (MN) degeneration. Hence, energy homeostasis is deeply implicated in the complex physiopathology of ALS and skeletal muscle has emer...

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Literature Corpus work: df5c4bd4-4917-5fad-925a-f39064e51e1a
DOI: 10.1101/2024.07.17.24309945

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