Article

Progressive muscle metabolic reprogramming in asymptomatic ALS gene mutation carriers

2025-12-17

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rapidly fatal neurodegenerative disorder characterized by motor neuron loss leading to extensive paralysis. There is emerging evidence that the disease involves a prolonged presymptomatic period during which motor function is preserved. Understanding the molecular mechanisms involved is key as the presymptomatic phase represents a critical window of opportunity for early in...

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Literature Corpus work: 3a162c7e-a7fe-5f08-8612-8278e8925471
DOI: 10.64898/2025.12.15.694300

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