Article

Intratumoral plasma cells mediate CD8+ T cell infiltration and successful immune checkpoint blockade therapy in <i>de novo</i> MPNSTs

2026-02-20

Abstract excerpt

<h4>Background</h4> The role of intratumoral plasma cells in immune checkpoint blockade (ICB) therapy has never been tested although their presence is linked with improved patient response and survival. Malignant peripheral nerve sheath tumors (MPNSTs) are deadly sarcomas with minimal responsiveness to ICB therapies. Strikingly, drugs inhibiting cyclin-dependent kinases 4/6 (CDK4/6) and MEK sensitize de novo MPN...

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Literature Corpus work: c39cf3d1-4a9b-5961-83fe-2832f198165b
DOI: 10.64898/2026.02.18.706680

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