Article

Spatial Single-Cell Atlas Reveals KSHV-Driven Broad Cellular Reprogramming, Progenitor Expansion, Immune and Vascular Remodeling in Kaposi’s Sarcoma

2025-09-05

Abstract excerpt

<h4>Summary</h4> Kaposi’s sarcoma (KS) is a highly inflammatory, angiogenic tumor driven by Kaposi’s sarcoma-associated herpesvirus (KSHV), yet the origins of tumor cells and mechanisms of progression remain unclear. Here, we present the first spatial single-cell atlas of KS, profiling 256 samples across patch, plaque, and nodular lesions and normal controls. We identify CD34⁺ progenitor lymphatic endothelial cel...

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Literature Corpus work: 691578be-6cea-56db-8730-2477b72dc0e8
DOI: 10.1101/2025.09.01.673567

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