Article

The Cell Surface Proteome of Malignant Peripheral Nerve Sheath Tumors Reveals Therapeutic Targets

2026-03-14

Abstract excerpt

<h4>ABSTRACT</h4> Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas and the most common cause of disease-associated death for Neurofibromatosis Type 1 (NF1) patients. In the context of NF1, MPSNTs develop from benign premalignant precursors. The transition to malignancy is usually accompanied by loss of the polycomb repressive complex 2 (PRC2), leading to aberrant upregulation...

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Literature Corpus work: d18d64e2-962c-5974-b512-157644d9ff21
DOI: 10.64898/2026.03.11.711103

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