B cells are associated with survival and immunotherapy response in sarcoma.

doi:10.1038/s41586-019-1906-8

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Article

B cells are associated with survival and immunotherapy response in sarcoma.

Nature - 1 Jan 2020

Petitprez Florent, de Reyniès Aurélien, Keung Emily Z, Chen Tom Wei-Wu, Sun Cheng-Ming, Calderaro Julien, Jeng Yung-Ming, Hsiao Li-Ping, Lacroix Laetitia, Bougoüin Antoine, Moreira Marco, Lacroix Guillaume, Natario Ivo, Adam Julien, Lucchesi Carlo, Laizet Yec Han, Toulmonde Maud, Burgess Melissa A, Bolejack Vanessa, Reinke Denise, Wani Khalid M, Wang Wei-Lien, Lazar Alexander J, Roland Christina L, Wargo Jennifer A, Italiano Antoine, Sautès-Fridman Catherine, Tawbi Hussein A, Fridman Wolf H

Abstract excerpt

Soft-tissue sarcomas represent a heterogeneous group of cancer, with more than 50 histological subtypes1,2. The clinical presentation of patients with different subtypes is often atypical, and responses to therapies such as immune checkpoint blockade vary widely3,4. To explain this clinical variability, here we study gene expression profiles in 608 tumours across subtypes of soft-tissue sarcoma. We establish an...

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Identifiers

PMID: 31942077
DOI: 10.1038/s41586-019-1906-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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