Article

SARC028 samples reveal an interplay between TGF-beta, interferon signaling and low HLA class I expression as contributors to Ewing sarcoma checkpoint blockade resistance

2025-03-28

Abstract excerpt

<h4>Purpose</h4> Ewing sarcoma, in contrast to some adult sarcoma subtypes, generally does not respond to single agent immunotherapy targeting PD1. The features of Ewing sarcoma that preclude the effectiveness of immunotherapy remain largely unknown. To address this question, we utilized biopsies from patients with Ewing sarcoma obtained pre- and post-pembrolizumab (anti-PD1) therapy from the phase 2 clinical tri...

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Literature Corpus work: 10fb5f3e-fb4e-599b-96f3-f71ac46abdfb
DOI: 10.1101/2025.03.26.645492

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