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Interferon signaling underlies radiotherapy responses in malignant peripheral nerve sheath tumors (MPNSTs)

2025-03-13

Abstract excerpt

<h4>Summary</h4> Malignant peripheral nerve sheath tumors (MPNSTs) have poor outcomes despite multimodal treatment with surgery, radiation, and systemic therapy. Here, we combine bulk and single cell transcriptomics, genome wide CRISPRi screens, and multiplatform molecular analysis across MPNST cells, mouse allograft models, and human patient samples to understand the mediators of radiation response. Our data rev...

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Literature Corpus work
a7e3d6db-4e3e-587b-8b1e-225c9ff63b9b
DOI
10.1101/2025.03.09.642167
Open publication

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Interferon signaling underlies radiotherapy responses in malignant peripheral nerve sheath tumors (MPNSTs)DOI 10.1101/2025.03.09.642167
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