Article

The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibition

2023-05-23

Abstract excerpt

Sarcomas are comprised of diverse bone and connective tissue tumors with few effective therapeutic options for locally advanced unresectable and/or metastatic disease. Recent advances in immunotherapy, in particular immune checkpoint inhibition (ICI), have shown promising outcomes in several cancer indications. Unfortunately, ICI therapy has provided only modest clinical responses and seems moderately effective in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: df387cd5-1fb4-5297-8c04-f41ff34d664f
DOI: 10.1101/2023.05.20.23290277

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The interplay between neoantigens and immune cells in sarcomas treated with checkpoint inhibitionDOI 10.1101/2023.05.20.23290277Read

Single-Cell Profiling of Sarcomas from Archival Tissue Reveals Programs Associated with Resistance to Immune Checkpoint BlockadeSemantic proximity Read

The immune subtypes and landscape of sarcomasSemantic proximity Read

Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypesSemantic proximity Read

The Immune Landscape of CancerSemantic proximity Read

B cells are associated with survival and immunotherapy response in sarcoma.Semantic proximity Read

Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint BlockadeSemantic proximity Read

The Study of Sarcoma Microenvironment Heterogeneity Associated With Prognosis Based on an Immunogenomic Landscape AnalysisSemantic proximity Read

Identification of Tumor Microenvironment-Related Prognostic Genes in SarcomaSemantic proximity Read

Comprehensive analysis of immune infiltration and gene expression for predicting survival in patients with sarcomas.Semantic proximity Read

Integrated modeling to implicate evolving neoantigen-T cell interplays and immunotherapy efficacy in tumorsSemantic proximity Read

Predicted CD4 + T cell infiltration levels could indicate better overall survival in sarcoma patientsSemantic proximity Read

Immune-related prognostic genes signatures in the tumor microenvironment of sarcomaSemantic proximity Read