Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epithelial-to-mesenchymal transition drives cancer genomic instability

30 Apr 2025

Abstract excerpt

Epithelial-to-Mesenchymal Transition (EMT) is a form of embryonic cell plasticity reactivated in adult cells during injury and cancer. A recent study by Perelli et al. demonstrates that EMT confers an evolutionary advantage to tumors by inducing chromosomal instability, structural genomic rearrangements and chromothripsis, thus favoring the emergence of high-fitness malignant clones.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40301945
DOI: 10.1186/s13046-025-03402-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epithelial-to-mesenchymal transition drives cancer genomic instabilityPMID 40301945Read ↗

Evolutionary fingerprints of epithelial-to-mesenchymal transition.Semantic proximity Read ↗

Evolutionary fingerprints of EMT in pancreatic cancersSemantic proximity Read ↗

Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistanceSemantic proximity Read ↗

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?Semantic proximity Read ↗

Epithelial-mesenchymal plasticity—engaging stemness in an interplay of phenotypesSemantic proximity Read ↗

Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer.Semantic proximity Read ↗

Deciphering the Dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in Tumor ProgressionSemantic proximity Read ↗

The many faces of cancer evolutionSemantic proximity Read ↗

Update on Epithelial-Mesenchymal Plasticity in Cancer ProgressionSemantic proximity Read ↗

Genome remodeling upon mesenchymal tumor cell fusion contributes to tumor progression and metastatic spreadSemantic proximity Read ↗

Mechanisms of Disease: epithelial–mesenchymal transition—does cellular plasticity fuel neoplastic progression?Semantic proximity Read ↗

Epigenetic Regulation of Cancer Cell Plasticity and Its Impact on Therapy ResistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.