Article

Tauopathy in the <i>APP</i> <sub>swe</sub> / <i>PS1</i> <sub>ΔE9</sub> mouse model of familial Alzheimer’s disease

2018-08-31

Abstract excerpt

Despite compelling evidence that the accumulation of amyloid-beta (Aβ) promotes cortical MAPT (tau) aggregation in familial and idiopathic Alzheimer’s disease (AD), murine models of cerebral amyloidosis are not considered to develop tau-associated pathology. The absence of neurofibrillary lesions in amyloidosis mice remains a challenge for the amyloidocentric paradigm of AD pathogenesis. It has resulted in the gen...

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Literature Corpus work: c37e5aae-8b60-5157-ab95-729464061ffc
DOI: 10.1101/405647

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