Article

Catalytic degradation of circulating targets with FcRn-mediated cycling LYTACs

2025-01-13

Abstract excerpt

Circulating proteins are common targets for the discovery of occupancy-based inhibitors including monoclonal antibodies. Effective inhibition of target pathogenicity with blocking approaches, however, is often challenged by target parameters that lead to insufficient occupancy and/or incomplete pharmacology limited by only single site binding. Extracellular targeted protein degradation approaches, such as lysosoma...

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Literature Corpus work: c3751df4-f094-5558-935f-d16c9d037e2e
DOI: 10.1101/2025.01.12.632472

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