Article
Extending human IgG half-life using structure-guided design.
mAbs - 1 Oct 2018
Booth Brian J, Ramakrishnan Boopathy, Narayan Kristin, Wollacott Andrew M, Babcock Gregory J, Shriver Zachary, Viswanathan Karthik
Abstract excerpt
Engineering of antibodies for improved pharmacokinetics through enhanced binding to the neonatal Fc receptor (FcRn) has been demonstrated in transgenic mice, non-human primates and humans. Traditionally, such approaches have largely relied on random mutagenesis and display formats, which fail to address related critical attributes of the antibody, such as effector functions or biophysical stability. We have...
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