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pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

23 Dec 2014

Abstract excerpt

The Fc domain of IgG has been the target of multiple mutational studies aimed at altering the pH-dependent IgG/FcRn interaction to modulate IgG pharmacokinetics. These studies have yielded antibody variants with disparate pharmacokinetic characteristics, ranging from extended in vivo half-life to those exhibiting extremely rapid clearance. To better understand pH-dependent binding parameters that govern these...

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PMID: 25538249
DOI: 10.1074/jbc.m114.603712

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