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AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion <i>in vivo</i>

2026-07-06

Abstract excerpt

Immunoglobulins (e.g., IgGs) are critical effectors of the adaptive immune system that when overexpressed or dysregulated can result in autoimmune diseases. Thus, depletion of IgGs can be a promising therapeutic avenue. Here we developed g enetically- e ncoded lysosome targeting c himeras (GELYTACs) that target circulating IgGs for clearance and degradation. The GELYTACs comprised two protein modules derived fr...

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Literature Corpus work
99502144-ce4f-5fb0-aca8-6ca0057b32fa
DOI
10.64898/2026.07.05.736665
Open publication

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AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion <i>in vivo</i>DOI 10.64898/2026.07.05.736665
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