Article
An Fc variant with two mutations confers prolonged serum half-life and enhanced effector functions on IgG antibodies.
Experimental & molecular medicine - 1 Nov 2022
Ko Sanghwan, Park Sora, Sohn Myung Ho, Jo Migyeong, Ko Byoung Joon, Na Jung-Hyun, Yoo Hojin, Jeong Ae Lee, Ha Kyungsoo, Woo Ju Rang, Lim Chungsu, Shin Jung Hyu, Lee Dohyun, Choi So-Young, Jung Sang Taek
Abstract excerpt
The pH-selective interaction between the immunoglobulin G (IgG) fragment crystallizable region (Fc region) and the neonatal Fc receptor (FcRn) is critical for prolonging the circulating half-lives of IgG molecules through intracellular trafficking and recycling. By using directed evolution, we successfully identified Fc mutations that improve the pH-dependent binding of human FcRn and prolong the serum...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.