Article
Fc Engineering: Tailored Synthetic Human IgG1-Fc Repertoire for High-Affinity Interaction with FcRn at pH 6.0.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Saxena Abhishek, Bai Bingxin, Hou Shin-Chen, Jiang Lianlian, Ying Tianlei, Miersch Shane, Sidhu Sachdev S, Wu Donghui
Abstract excerpt
The therapeutic efficacy of an antibody drug depends on the variable domains and on the constant crystallizable fragment (Fc). IgG variable domains have been the targets of extensive molecular engineering in search of more specific binders with higher affinities for their targets. Similarly, Fc engineering approaches have led to modulating both the immune effector responses and serum half-lives of therapeutic...
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